This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for FUZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FUZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FUZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,512,565–49,513,700 | 300.2 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 285.4 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 279.2 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 257.1 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 232.7 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 219.7 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 175.0 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 172.9 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 148.8 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 147.4 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 140.9 kb | Distal (>10kb) Multiome | 625 | |
| chr19:49,676,058–49,678,754 | 136.4 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 132.5 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 122.2 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 66.8 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 46.6 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 10.8 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 7.7 kb | Proximal (<10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 4.3 kb | Proximal (<10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 190 bp | At TSS Multiome | 650 | |
| chr19:49,817,356–49,818,721 | 4.9 kb | Proximal (<10kb) Multiome | 784 | |
| chr19:49,850,394–49,852,067 | 37.6 kb | Distal (>10kb) Multiome | 862 | |
| chr19:49,866,817–49,868,124 | 54.1 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 56.3 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 64.5 kb | Distal (>10kb) Multiome | 1153 | |
| chr19:49,889,853–49,891,381 | 77.2 kb | Distal (>10kb) Multiome | 640 | |
| chr19:49,928,884–49,930,473 | 116.6 kb | Distal (>10kb) Multiome | 1141 | |
| chr19:49,987,157–49,987,669 | 174.1 kb | Distal (>10kb) Multiome | 1095 | |
| chr19:50,024,875–50,026,285 | 212.4 kb | Distal (>10kb) Multiome | 1137 |
Genomic view of the FUZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.