Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FTSJ3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FTSJ3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FTSJ3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,522,589–63,523,803 | 303.9 kb | Distal (>10kb) Multiome | 705 | |
| chr17:63,549,660–63,551,443 | 276.7 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:63,600,715–63,601,423 | 226.2 kb | Distal (>10kb) Multiome | 1122 | |
| chr17:63,621,512–63,623,359 | 205.0 kb | Distal (>10kb) Multiome | 956 | |
| chr17:63,698,705–63,701,428 | 126.9 kb | Distal (>10kb) Multiome | 663 | |
| chr17:63,741,119–63,742,935 | 85.2 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:63,773,179–63,774,727 | 53.3 kb | Distal (>10kb) Multiome | 1169 | |
| chr17:63,826,794–63,828,024 | 294 bp | At TSS Multiome | 1008 | |
| chr17:63,834,919–63,835,138 | 7.8 kb | Proximal (<10kb) | 307 | |
| chr17:63,841,547–63,843,442 | 15.9 kb | Distal (>10kb) Multiome | 1203 | |
| chr17:63,848,836–63,849,566 | 22.1 kb | Distal (>10kb) Multiome | 658 | |
| chr17:63,960,119–63,962,604 | 134.8 kb | Distal (>10kb) Multiome | 445 | |
| chr17:63,998,051–63,998,826 | 171.3 kb | Distal (>10kb) Multiome | 408 |
Genomic view of the FTSJ3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.