This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for FTSJ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FTSJ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FTSJ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,836,213–47,837,023 | 639.5 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chrX:48,021,260–48,021,892 | 454.7 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chrX:48,071,368–48,072,042 | 404.4 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chrX:48,475,845–48,476,469 | 28 bp | At TSS Multiome | 613 | |
| chrX:48,508,766–48,509,247 | 32.7 kb | Distal (>10kb) Multiome | 400 | |
| chrX:48,521,369–48,522,158 | 45.6 kb | Distal (>10kb) Multiome | 519 | |
| chrX:48,539,185–48,540,294 | 63.5 kb | Distal (>10kb) Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 98.4 kb | Distal (>10kb) Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 121.7 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 200.3 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 220.5 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 261.2 kb | Distal (>10kb) Multiome | 580 |
Genomic view of the FTSJ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.