This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for FTO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FTO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FTO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:53,433,981–53,435,683 | 269.6 kb | Distal (>10kb) Multiome | 929 | |
| chr16:53,502,382–53,504,919 | 200.7 kb | Distal (>10kb) Multiome | 983 | |
| chr16:53,703,446–53,704,426 | 178 bp | At TSS Multiome | 861 | |
| chr16:54,927,769–54,931,725 | 1226.6 kb | Distal (>10kb) Multiome HiCAR | 746 | |
| chr16:55,056,580–55,057,535 | 1352.7 kb | Distal (>10kb) Multiome HiCAR | 230 |
Genomic view of the FTO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.