Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FSBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FSBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FSBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,234,175–94,235,153 | 202.4 kb | Distal (>10kb) Multiome | 358 | |
| chr8:94,239,933–94,240,669 | 196.7 kb | Distal (>10kb) Multiome | 130 | |
| chr8:94,261,952–94,262,867 | 174.6 kb | Distal (>10kb) Multiome | 569 | |
| chr8:94,436,616–94,437,535 | 33 bp | At TSS Multiome | 334 | |
| chr8:94,440,682–94,441,120 | 3.7 kb | Proximal (<10kb) | 269 | |
| chr8:94,474,579–94,475,673 | 38.1 kb | Distal (>10kb) Multiome | 722 | |
| chr8:94,553,030–94,554,248 | 116.7 kb | Distal (>10kb) Multiome | 938 | |
| chr8:94,605,142–94,605,744 | 168.6 kb | Distal (>10kb) Multiome | 82 | |
| chr8:94,638,867–94,642,864 | 202.3 kb | Distal (>10kb) Multiome | 705 | |
| chr8:94,719,362–94,720,432 | 282.9 kb | Distal (>10kb) Multiome | 1182 |
Genomic view of the FSBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.