This gene encodes a protein that contains a PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain at the N-terminus followed by a FERM domain. The encoded protein is involved in signal transduction. The PDZ domain is thought to function in protein-protein interactions, mainly by binding to specific C-terminal peptides of other proteins. The FERM domain is found in proteins that are localized to the plasma membrane and are associated with the cytoskeleton. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for FRMPD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRMPD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRMPD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:106,999,512–107,000,567 | 449.4 kb | Distal (>10kb) Multiome HiCAR | 501 | |
| chrX:107,205,778–107,206,873 | 243.2 kb | Distal (>10kb) Multiome | 440 | |
| chrX:107,324,517–107,325,343 | 124.7 kb | Distal (>10kb) Multiome | 215 | |
| chrX:107,445,740–107,445,917 | 3.7 kb | Proximal (<10kb) | 17 | |
| chrX:107,449,001–107,449,401 | 249 bp | At TSS | 87 | |
| chrX:107,449,526–107,450,551 | at TSS | At TSS | 187 | |
| chrX:107,451,187–107,451,640 | 1.5 kb | Proximal (<10kb) | 106 | |
| chrX:107,451,780–107,452,209 | 2.1 kb | Proximal (<10kb) | 90 | |
| chrX:107,628,178–107,629,161 | 178.8 kb | Distal (>10kb) Multiome | 409 | |
| chrX:107,654,846–107,655,657 | 205.6 kb | Distal (>10kb) Multiome | 393 | |
| chrX:107,731,822–107,732,545 | 282.5 kb | Distal (>10kb) Multiome | 347 |
Genomic view of the FRMPD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.