This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for FRMD4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRMD4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRMD4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:13,440,173–13,440,755 | 890.4 kb | Distal (>10kb) Multiome | 414 | |
| chr10:13,528,519–13,529,578 | 801.9 kb | Distal (>10kb) Multiome | 267 | |
| chr10:13,586,728–13,587,229 | 744.0 kb | Distal (>10kb) Multiome | 812 | |
| chr10:13,690,233–13,691,095 | 640.3 kb | Distal (>10kb) Multiome | 202 | |
| chr10:13,707,398–13,707,910 | 623.4 kb | Distal (>10kb) Multiome | 353 | |
| chr10:13,881,844–13,882,604 | 448.6 kb | Distal (>10kb) Multiome | 306 | |
| chr10:13,891,486–13,892,451 | 439.0 kb | Distal (>10kb) Multiome | 174 | |
| chr10:13,930,150–13,930,698 | 400.5 kb | Distal (>10kb) Multiome | 157 | |
| chr10:14,088,721–14,089,527 | 241.6 kb | Distal (>10kb) Multiome | 134 | |
| chr10:14,174,121–14,174,476 | at TSS | At TSS | 131 | |
| chr10:14,184,884–14,186,692 | 145.2 kb | Distal (>10kb) Multiome | 755 | |
| chr10:14,603,765–14,604,803 | 273.4 kb | Distal (>10kb) Multiome | 535 |
Genomic view of the FRMD4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.