Predicted to be involved in regulation of post-transcriptional gene silencing. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FOCAD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOCAD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOCAD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:19,934,217–19,934,978 | 749.7 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr9:20,621,544–20,623,597 | 61.7 kb | Distal (>10kb) Multiome | 731 | |
| chr9:20,683,443–20,685,033 | 21 bp | At TSS Multiome | 898 | |
| chr9:20,692,583–20,692,795 | 8.3 kb | Proximal (<10kb) | 267 |
Genomic view of the FOCAD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.