A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for FN3KRP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FN3KRP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FN3KRP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:82,417,993–82,419,018 | 298.2 kb | Distal (>10kb) Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 265.9 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 258.1 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 222.0 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 219.4 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 197.1 kb | Distal (>10kb) Multiome | 869 | |
| chr17:82,647,682–82,648,684 | 68.1 kb | Distal (>10kb) Multiome | 874 | |
| chr17:82,697,983–82,699,271 | 17.9 kb | Distal (>10kb) Multiome | 623 | |
| chr17:82,715,983–82,717,178 | 138 bp | At TSS Multiome | 744 | |
| chr17:82,735,174–82,736,034 | 18.8 kb | Distal (>10kb) Multiome | 649 | |
| chr17:82,751,094–82,752,780 | 35.0 kb | Distal (>10kb) Multiome | 987 | |
| chr17:82,754,710–82,755,244 | 38.2 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the FN3KRP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.