A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for FN3K. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FN3K upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FN3K, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:82,450,369–82,451,002 | 284.8 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 277.1 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 240.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 238.3 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 216.0 kb | Distal (>10kb) Multiome | 869 | |
| chr17:82,647,682–82,648,684 | 87.0 kb | Distal (>10kb) Multiome | 874 | |
| chr17:82,697,983–82,699,271 | 36.8 kb | Distal (>10kb) Multiome | 623 | |
| chr17:82,715,983–82,717,178 | 19.0 kb | Distal (>10kb) Multiome | 744 | |
| chr17:82,735,174–82,736,034 | 84 bp | At TSS Multiome | 649 | |
| chr17:82,751,094–82,752,780 | 16.1 kb | Distal (>10kb) Multiome | 987 | |
| chr17:82,754,710–82,755,244 | 19.3 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the FN3K locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.