This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for FLVCR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLVCR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLVCR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:75,278,060–75,280,702 | 300.0 kb | Distal (>10kb) Multiome | 928 | |
| chr14:75,293,606–75,295,425 | 284.4 kb | Distal (>10kb) Multiome | 759 | |
| chr14:75,295,693–75,296,382 | 282.4 kb | Distal (>10kb) Multiome | 471 | |
| chr14:75,419,070–75,419,695 | 159.1 kb | Distal (>10kb) Multiome | 358 | |
| chr14:75,427,222–75,428,490 | 150.7 kb | Distal (>10kb) Multiome | 640 | |
| chr14:75,452,945–75,453,577 | 125.3 kb | Distal (>10kb) Multiome | 408 | |
| chr14:75,577,727–75,579,221 | 46 bp | At TSS Multiome | 646 | |
| chr14:75,580,406–75,580,628 | 1.8 kb | Proximal (<10kb) | 13 | |
| chr14:75,604,930–75,606,141 | 26.9 kb | Distal (>10kb) Multiome | 195 | |
| chr14:75,646,886–75,647,914 | 68.9 kb | Distal (>10kb) Multiome HiCAR | 156 | |
| chr14:75,660,453–75,661,746 | 82.5 kb | Distal (>10kb) Multiome | 786 | |
| chr14:75,711,559–75,712,330 | 133.4 kb | Distal (>10kb) Multiome | 434 | |
| chr14:75,972,579–75,973,063 | 394.2 kb | Distal (>10kb) Multiome HiCAR | 56 |
Genomic view of the FLVCR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.