This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FLT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:180,352,255–180,354,009 | 265.7 kb | Distal (>10kb) Multiome | 450 | |
| chr5:180,493,929–180,495,203 | 124.8 kb | Distal (>10kb) Multiome | 803 | |
| chr5:180,618,726–180,619,463 | 41 bp | At TSS Multiome | 289 | |
| chr5:180,648,868–180,649,861 | 30.1 kb | Distal (>10kb) Multiome | 281 | |
| chr5:180,802,126–180,804,080 | 183.7 kb | Distal (>10kb) Multiome | 796 | |
| chr5:180,809,580–180,811,300 | 191.2 kb | Distal (>10kb) Multiome | 1018 | |
| chr5:180,831,123–180,831,970 | 212.4 kb | Distal (>10kb) Multiome | 549 | |
| chr5:180,860,430–180,861,900 | 242.2 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the FLT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.