Transcription factors with Perturb-seq knockdown data for FLJ42969. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLJ42969 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLJ42969, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:101,041,585–101,042,308 | 9.7 kb | Proximal (<10kb) | 191 | |
| chr8:101,051,752–101,052,187 | at TSS | At TSS | 418 | |
| chr8:101,057,931–101,058,109 | 5.9 kb | Proximal (<10kb) | 26 |
Genomic view of the FLJ42969 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.