This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for FILIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FILIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FILIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,695,662–73,696,526 | 1638.7 kb | Distal (>10kb) Multiome HiCAR | 534 | |
| chr6:75,204,283–75,209,417 | 128.7 kb | Distal (>10kb) Multiome | 741 | |
| chr6:75,243,188–75,244,541 | 91.0 kb | Distal (>10kb) Multiome | 858 | |
| chr6:75,283,886–75,285,703 | 49.9 kb | Distal (>10kb) Multiome | 948 | |
| chr6:75,334,164–75,335,181 | 16 bp | At TSS Multiome | 265 | |
| chr6:75,348,793–75,350,207 | 14.8 kb | Distal (>10kb) Multiome | 378 | |
| chr6:75,601,534–75,603,064 | 267.2 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the FILIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.