The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FGF14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:102,393,776–102,395,161 | 7.9 kb | Proximal (<10kb) Multiome | 543 | |
| chr13:102,399,703–102,401,411 | 2.1 kb | Proximal (<10kb) Multiome | 331 | |
| chr13:102,401,930–102,402,839 | 25 bp | At TSS Multiome | 191 | |
| chr13:102,405,813–102,405,986 | 3.4 kb | Proximal (<10kb) | 39 | |
| chr13:102,591,759–102,592,780 | 189.8 kb | Distal (>10kb) Multiome | 578 | |
| chr13:102,596,004–102,597,912 | 194.4 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the FGF14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.