FCHO1

FCH and mu domain containing endocytic adaptor 1 | KIAA0290

Enables AP-2 adaptor complex binding activity. Involved in several processes, including T cell receptor signaling pathway; clathrin coat assembly; and clathrin-dependent endocytosis. Located in cytosol; nucleoplasm; and plasma membrane. Is active in clathrin-coated pit. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 22 terms

AP-2 adaptor complex binding (GO:0035612)T cell receptor signaling pathway (GO:0050852)clathrin coat assembly (GO:0048268)clathrin coat assembly (GO:0048268)clathrin coat assembly (GO:0048268)clathrin-coated pit (GO:0005905)clathrin-coated pit (GO:0005905)clathrin-coated pit (GO:0005905)clathrin-coated pit (GO:0005905)clathrin-coated vesicle (GO:0030136)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)nucleoplasm (GO:0005654)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of T cell activation (GO:0050870)postsynaptic endocytic zone (GO:0098843)protein binding (GO:0005515)

Expression (TPM)

TFs regulating FCHO1 0 TFs

Transcription factors with Perturb-seq knockdown data for FCHO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCHO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FCHO1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCHO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,448,174–17,448,841	299.1 kb	Distal (>10kb) Multiome	392
chr19:17,488,739–17,489,689	258.6 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	235.5 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	207.9 kb	Distal (>10kb) Multiome	725
chr19:17,555,194–17,556,523	192.2 kb	Distal (>10kb) Multiome	713
chr19:17,576,463–17,577,455	170.8 kb	Distal (>10kb) Multiome	236
chr19:17,579,580–17,580,242	167.8 kb	Distal (>10kb) Multiome	281
chr19:17,605,468–17,607,009	141.5 kb	Distal (>10kb) Multiome	1030
chr19:17,686,280–17,688,656	61.0 kb	Distal (>10kb) Multiome	586
chr19:17,719,144–17,719,957	28.3 kb	Distal (>10kb) Multiome	585
chr19:17,747,227–17,748,170	107 bp	At TSS Multiome	503
chr19:17,762,487–17,762,985	14.9 kb	Distal (>10kb) Multiome	199
chr19:17,778,112–17,778,869	30.7 kb	Distal (>10kb) Multiome	311
chr19:17,794,880–17,795,385	47.4 kb	Distal (>10kb) Multiome	465
chr19:17,829,926–17,831,824	83.2 kb	Distal (>10kb) Multiome	466
chr19:17,841,205–17,843,221	94.3 kb	Distal (>10kb) Multiome	545
chr19:17,847,546–17,848,187	100.0 kb	Distal (>10kb) Multiome	437
chr19:17,859,472–17,860,202	112.0 kb	Distal (>10kb) Multiome	822
chr19:17,873,769–17,874,763	126.5 kb	Distal (>10kb) Multiome	303
chr19:17,931,700–17,932,248	184.2 kb	Distal (>10kb) Multiome	136
chr19:17,932,373–17,933,607	185.1 kb	Distal (>10kb) Multiome	924
chr19:17,942,639–17,943,673	195.6 kb	Distal (>10kb) Multiome	302
chr19:17,947,203–17,950,613	202.5 kb	Distal (>10kb) Multiome	639
chr19:17,966,756–17,967,353	219.3 kb	Distal (>10kb) Multiome	127
chr19:18,007,024–18,008,451	260.4 kb	Distal (>10kb) Multiome	681

Genome Browser

Genomic view of the FCHO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.