This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for FBXO41. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO41 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO41, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:73,070,503–73,072,300 | 212.9 kb | Distal (>10kb) Multiome | 1016 | |
| chr2:73,111,353–73,113,710 | 171.4 kb | Distal (>10kb) Multiome | 903 | |
| chr2:73,156,488–73,157,075 | 127.6 kb | Distal (>10kb) Multiome | 419 | |
| chr2:73,175,306–73,176,433 | 108.7 kb | Distal (>10kb) Multiome | 499 | |
| chr2:73,176,845–73,177,711 | 106.9 kb | Distal (>10kb) Multiome | 779 | |
| chr2:73,202,161–73,203,581 | 81.9 kb | Distal (>10kb) Multiome | 227 | |
| chr2:73,214,088–73,214,797 | 70.1 kb | Distal (>10kb) Multiome | 870 | |
| chr2:73,232,770–73,234,882 | 49.9 kb | Distal (>10kb) Multiome | 1129 | |
| chr2:73,268,616–73,269,882 | 15.2 kb | Distal (>10kb) Multiome | 384 | |
| chr2:73,283,511–73,285,190 | 144 bp | At TSS Multiome | 734 | |
| chr2:73,291,197–73,292,186 | 7.0 kb | Proximal (<10kb) Multiome | 609 | |
| chr2:73,293,075–73,294,022 | 9.3 kb | Proximal (<10kb) Multiome | 382 | |
| chr2:73,385,262–73,386,724 | 101.5 kb | Distal (>10kb) Multiome | 893 |
Genomic view of the FBXO41 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.