Involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FBXL15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,119,389–102,122,276 | 299.2 kb | Distal (>10kb) Multiome | 934 | |
| chr10:102,132,334–102,133,845 | 286.9 kb | Distal (>10kb) Multiome | 968 | |
| chr10:102,151,480–102,152,882 | 267.6 kb | Distal (>10kb) Multiome | 1009 | |
| chr10:102,169,504–102,169,976 | 250.1 kb | Distal (>10kb) Multiome | 398 | |
| chr10:102,225,881–102,226,551 | 193.6 kb | Distal (>10kb) Multiome | 652 | |
| chr10:102,229,814–102,232,116 | 189.8 kb | Distal (>10kb) Multiome | 689 | |
| chr10:102,240,581–102,242,031 | 178.2 kb | Distal (>10kb) Multiome | 504 | |
| chr10:102,244,918–102,246,010 | 174.4 kb | Distal (>10kb) Multiome | 734 | |
| chr10:102,393,940–102,396,107 | 24.1 kb | Distal (>10kb) Multiome | 912 | |
| chr10:102,399,132–102,400,002 | 20.2 kb | Distal (>10kb) Multiome | 832 | |
| chr10:102,408,600–102,409,538 | 10.7 kb | Distal (>10kb) Multiome | 277 | |
| chr10:102,410,213–102,410,909 | 9.1 kb | Proximal (<10kb) Multiome | 148 | |
| chr10:102,418,158–102,422,381 | 180 bp | At TSS Multiome | 1097 | |
| chr10:102,422,562–102,423,126 | 3.1 kb | Proximal (<10kb) Multiome | 721 | |
| chr10:102,431,859–102,432,863 | 12.8 kb | Distal (>10kb) Multiome | 828 | |
| chr10:102,449,444–102,451,250 | 29.9 kb | Distal (>10kb) Multiome | 810 | |
| chr10:102,454,792–102,455,588 | 35.2 kb | Distal (>10kb) Multiome | 159 | |
| chr10:102,460,805–102,462,064 | 41.6 kb | Distal (>10kb) Multiome | 665 | |
| chr10:102,501,628–102,503,235 | 82.4 kb | Distal (>10kb) Multiome | 738 | |
| chr10:102,503,432–102,504,897 | 84.2 kb | Distal (>10kb) Multiome | 684 | |
| chr10:102,641,824–102,646,130 | 225.3 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 259.2 kb | Distal (>10kb) Multiome | 476 | |
| chr10:102,713,669–102,715,337 | 294.6 kb | Distal (>10kb) Multiome | 895 |
Genomic view of the FBXL15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.