This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,793,033–39,793,501 | 53.1 kb | Distal (>10kb) Multiome | 418 | |
| chr19:39,824,152–39,825,056 | 21.7 kb | Distal (>10kb) Multiome | 531 | |
| chr19:39,833,207–39,834,766 | 12.5 kb | Distal (>10kb) Multiome | 779 | |
| chr19:39,845,668–39,847,301 | 30 bp | At TSS Multiome | 854 | |
| chr19:39,970,370–39,971,611 | 124.7 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,996,681–39,997,502 | 150.7 kb | Distal (>10kb) Multiome | 898 | |
| chr19:40,055,898–40,056,369 | 209.8 kb | Distal (>10kb) Multiome | 746 | |
| chr19:40,090,491–40,091,099 | 244.5 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the FBL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.