The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for FAT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:125,306,182–125,306,546 | 8.4 kb | Proximal (<10kb) | 7 | |
| chr4:125,313,320–125,313,919 | 997 bp | At TSS | 226 | |
| chr4:125,314,050–125,318,038 | 97 bp | At TSS Multiome | 880 | |
| chr4:125,357,535–125,358,794 | 42.9 kb | Distal (>10kb) Multiome | 185 | |
| chr4:125,985,523–125,986,641 | 671.2 kb | Distal (>10kb) Multiome HiCAR | 201 |
Genomic view of the FAT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.