Predicted to be involved in ERAD pathway. Part of Hrd1p ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM8A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM8A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM8A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:17,167,353–17,167,906 | 432.8 kb | Distal (>10kb) Multiome HiCAR | 251 | |
| chr6:17,393,134–17,394,567 | 206.6 kb | Distal (>10kb) Multiome | 710 | |
| chr6:17,417,499–17,418,859 | 182.3 kb | Distal (>10kb) Multiome | 259 | |
| chr6:17,472,571–17,473,238 | 127.5 kb | Distal (>10kb) Multiome | 338 | |
| chr6:17,599,884–17,601,398 | 5 bp | At TSS Multiome | 972 | |
| chr6:17,705,487–17,707,240 | 106.5 kb | Distal (>10kb) Multiome | 1165 |
Genomic view of the FAM8A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.