Predicted to enable molecular condensate scaffold activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM81A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM81A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM81A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:59,104,922–59,105,729 | 267.8 kb | Distal (>10kb) Multiome | 716 | |
| chr15:59,371,762–59,373,314 | 132 bp | At TSS Multiome | 794 | |
| chr15:59,437,777–59,438,609 | 65.2 kb | Distal (>10kb) Multiome | 381 | |
| chr15:59,657,112–59,657,938 | 284.6 kb | Distal (>10kb) Multiome | 777 | |
| chr15:59,688,678–59,689,653 | 316.4 kb | Distal (>10kb) Multiome | 878 |
Genomic view of the FAM81A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.