Predicted to be located in Golgi apparatus; membrane; and microtubule organizing center. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM234B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM234B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM234B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,775,741–12,776,742 | 268.0 kb | Distal (>10kb) Multiome | 267 | |
| chr12:12,786,507–12,787,490 | 257.4 kb | Distal (>10kb) Multiome | 739 | |
| chr12:12,799,298–12,799,907 | 244.7 kb | Distal (>10kb) Multiome | 137 | |
| chr12:12,812,936–12,813,661 | 231.1 kb | Distal (>10kb) Multiome | 700 | |
| chr12:12,890,573–12,891,789 | 153.5 kb | Distal (>10kb) Multiome | 656 | |
| chr12:12,999,403–13,001,860 | 44.1 kb | Distal (>10kb) Multiome | 719 | |
| chr12:13,042,872–13,043,308 | 1.1 kb | Proximal (<10kb) | 20 | |
| chr12:13,044,080–13,044,940 | 118 bp | At TSS Multiome | 620 | |
| chr12:13,061,181–13,061,778 | 17.1 kb | Distal (>10kb) Multiome HiCAR | 180 | |
| chr12:13,100,982–13,102,043 | 57.0 kb | Distal (>10kb) Multiome | 629 | |
| chr12:13,255,750–13,256,547 | 211.6 kb | Distal (>10kb) Multiome | 625 | |
| chr12:13,278,080–13,278,892 | 234.1 kb | Distal (>10kb) Multiome | 312 |
Genomic view of the FAM234B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.