Transcription factors with Perturb-seq knockdown data for FAM204A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM204A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM204A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:117,496,597–117,497,102 | 845.5 kb | Distal (>10kb) Multiome HiCAR | 397 | |
| chr10:118,045,936–118,047,525 | 295.4 kb | Distal (>10kb) Multiome | 849 | |
| chr10:118,258,175–118,258,829 | 83.8 kb | Distal (>10kb) Multiome | 139 | |
| chr10:118,337,420–118,337,574 | 4.7 kb | Proximal (<10kb) | 7 | |
| chr10:118,337,696–118,337,837 | 4.5 kb | Proximal (<10kb) | 10 | |
| chr10:118,341,772–118,342,929 | 28 bp | At TSS Multiome | 675 | |
| chr10:118,594,191–118,595,168 | 252.3 kb | Distal (>10kb) Multiome | 278 | |
| chr10:118,595,650–118,596,766 | 253.9 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the FAM204A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.