Transcription factors with Perturb-seq knockdown data for FAM199X. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM199X upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM199X, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,918,585–103,919,659 | 247.2 kb | Distal (>10kb) Multiome | 303 | |
| chrX:104,111,937–104,113,017 | 53.9 kb | Distal (>10kb) Multiome | 274 | |
| chrX:104,156,439–104,157,507 | 9.6 kb | Proximal (<10kb) Multiome | 771 | |
| chrX:104,165,815–104,167,017 | 51 bp | At TSS Multiome | 651 |
Genomic view of the FAM199X locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.