Transcription factors with Perturb-seq knockdown data for FAM174C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM174C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM174C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:982,565–983,215 | 292.7 kb | Distal (>10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 291.0 kb | Distal (>10kb) Multiome | 829 | |
| chr19:1,000,142–1,000,881 | 275.2 kb | Distal (>10kb) Multiome | 399 | |
| chr19:1,020,611–1,022,069 | 254.1 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 249.0 kb | Distal (>10kb) Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 247.0 kb | Distal (>10kb) Multiome | 584 | |
| chr19:1,039,648–1,040,400 | 235.5 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 234.3 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 230.2 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 213.0 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 210.7 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 208.3 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 204.4 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 193.1 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 180.1 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 171.5 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 163.2 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 162.0 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 152.3 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 101.3 kb | Distal (>10kb) Multiome | 682 | |
| chr19:1,194,370–1,194,985 | 80.9 kb | Distal (>10kb) Multiome | 531 | |
| chr19:1,205,175–1,206,374 | 69.9 kb | Distal (>10kb) Multiome | 746 | |
| chr19:1,237,080–1,238,434 | 37.4 kb | Distal (>10kb) Multiome | 430 | |
| chr19:1,239,513–1,242,539 | 33.8 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,244,253–1,244,857 | 31.0 kb | Distal (>10kb) Multiome | 590 | |
| chr19:1,247,981–1,252,501 | 24.5 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 16.1 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 6.2 kb | Proximal (<10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 205 bp | At TSS Multiome | 967 | |
| chr19:1,279,769–1,280,008 | 4.2 kb | Proximal (<10kb) | 378 | |
| chr19:1,285,317–1,286,108 | 10.2 kb | Distal (>10kb) Multiome | 277 | |
| chr19:1,354,303–1,355,411 | 79.4 kb | Distal (>10kb) Multiome | 688 | |
| chr19:1,383,122–1,384,333 | 108.1 kb | Distal (>10kb) Multiome HiCAR | 1228 | |
| chr19:1,401,101–1,401,839 | 126.0 kb | Distal (>10kb) Multiome | 540 | |
| chr19:1,406,589–1,408,783 | 131.9 kb | Distal (>10kb) Multiome | 911 | |
| chr19:1,415,008–1,415,721 | 140.0 kb | Distal (>10kb) Multiome | 597 | |
| chr19:1,437,988–1,438,998 | 162.8 kb | Distal (>10kb) Multiome | 1076 | |
| chr19:1,444,785–1,447,383 | 169.7 kb | Distal (>10kb) Multiome | 797 | |
| chr19:1,455,191–1,456,421 | 180.3 kb | Distal (>10kb) Multiome | 491 | |
| chr19:1,468,941–1,469,903 | 193.7 kb | Distal (>10kb) Multiome | 242 | |
| chr19:1,470,088–1,471,597 | 195.2 kb | Distal (>10kb) Multiome | 544 | |
| chr19:1,478,772–1,479,848 | 203.8 kb | Distal (>10kb) Multiome | 857 | |
| chr19:1,489,566–1,491,829 | 215.3 kb | Distal (>10kb) Multiome | 836 | |
| chr19:1,507,230–1,508,699 | 232.6 kb | Distal (>10kb) Multiome | 596 | |
| chr19:1,512,960–1,513,686 | 237.6 kb | Distal (>10kb) Multiome | 541 | |
| chr19:1,523,798–1,524,624 | 248.5 kb | Distal (>10kb) Multiome | 263 | |
| chr19:1,566,277–1,568,916 | 291.2 kb | Distal (>10kb) Multiome | 748 |
Genomic view of the FAM174C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.