Transcription factors with Perturb-seq knockdown data for FAM157C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM157C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM157C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:89,816,022–89,817,100 | 289.7 kb | Distal (>10kb) Multiome | 995 | |
| chr16:89,827,667–89,829,190 | 278.0 kb | Distal (>10kb) Multiome | 784 | |
| chr16:89,872,618–89,874,723 | 232.3 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:89,917,809–89,919,023 | 187.8 kb | Distal (>10kb) Multiome | 986 | |
| chr16:89,921,530–89,925,204 | 183.2 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,925,437–89,926,738 | 180.2 kb | Distal (>10kb) Multiome | 654 | |
| chr16:89,972,039–89,973,313 | 133.8 kb | Distal (>10kb) Multiome | 965 | |
| chr16:90,018,651–90,020,274 | 86.8 kb | Distal (>10kb) Multiome | 634 | |
| chr16:90,046,432–90,047,827 | 59.6 kb | Distal (>10kb) Multiome | 700 | |
| chr16:90,077,247–90,078,026 | 29.0 kb | Distal (>10kb) Multiome HiCAR | 412 | |
| chr16:90,081,997–90,082,775 | 24.3 kb | Distal (>10kb) Multiome HiCAR | 755 | |
| chr16:90,097,135–90,097,345 | 9.1 kb | Proximal (<10kb) | 18 |
Genomic view of the FAM157C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.