Predicted to be involved in lipid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM135B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM135B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM135B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:138,189,427–138,191,275 | 307.4 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr8:138,259,894–138,260,802 | 237.1 kb | Distal (>10kb) Multiome | 295 | |
| chr8:138,487,253–138,487,656 | 9.6 kb | Proximal (<10kb) | 11 | |
| chr8:138,496,321–138,497,981 | 38 bp | At TSS Multiome | 231 | |
| chr8:138,500,475–138,500,717 | 3.2 kb | Proximal (<10kb) | 26 |
Genomic view of the FAM135B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.