Transcription factors with Perturb-seq knockdown data for FAM131B-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM131B-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM131B-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:143,263,111–143,264,043 | 117.5 kb | Distal (>10kb) Multiome | 857 | |
| chr7:143,284,394–143,285,772 | 96.1 kb | Distal (>10kb) Multiome | 381 | |
| chr7:143,287,670–143,288,978 | 92.7 kb | Distal (>10kb) Multiome | 878 | |
| chr7:143,345,279–143,346,282 | 35.4 kb | Distal (>10kb) Multiome | 433 | |
| chr7:143,361,157–143,363,235 | 18.3 kb | Distal (>10kb) Multiome | 388 | |
| chr7:143,380,012–143,382,328 | 119 bp | At TSS Multiome | 946 | |
| chr7:143,387,556–143,387,961 | 6.5 kb | Proximal (<10kb) | 115 | |
| chr7:143,388,345–143,388,991 | 7.3 kb | Proximal (<10kb) | 77 | |
| chr7:143,389,538–143,390,929 | 8.5 kb | Proximal (<10kb) | 117 | |
| chr7:143,405,536–143,406,754 | 25.1 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr7:143,407,435–143,409,651 | 27.9 kb | Distal (>10kb) Multiome | 459 |
Genomic view of the FAM131B-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.