Transcription factors with Perturb-seq knockdown data for FAM117B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM117B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM117B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:202,374,983–202,377,090 | 258.9 kb | Distal (>10kb) Multiome | 979 | |
| chr2:202,417,747–202,419,134 | 216.2 kb | Distal (>10kb) Multiome | 197 | |
| chr2:202,494,924–202,495,550 | 139.8 kb | Distal (>10kb) Multiome | 49 | |
| chr2:202,588,516–202,589,312 | 46.1 kb | Distal (>10kb) Multiome | 565 | |
| chr2:202,634,508–202,636,378 | 147 bp | At TSS Multiome | 995 | |
| chr2:202,870,773–202,872,210 | 236.6 kb | Distal (>10kb) Multiome | 799 | |
| chr2:202,911,342–202,912,577 | 277.1 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the FAM117B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.