The protein encoded by this gene belongs to the FAM114 family and may play a role in neuronal cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for FAM114A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM114A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM114A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:38,662,974–38,665,390 | 202.5 kb | Distal (>10kb) Multiome | 759 | |
| chr4:38,666,747–38,667,842 | 200.6 kb | Distal (>10kb) Multiome | 769 | |
| chr4:38,672,084–38,673,018 | 195.3 kb | Distal (>10kb) Multiome | 382 | |
| chr4:38,723,814–38,724,694 | 143.4 kb | Distal (>10kb) Multiome | 170 | |
| chr4:38,753,004–38,753,507 | 114.6 kb | Distal (>10kb) Multiome | 401 | |
| chr4:38,860,753–38,861,131 | 6.7 kb | Proximal (<10kb) | 116 | |
| chr4:38,867,290–38,868,855 | 70 bp | At TSS Multiome | 597 | |
| chr4:39,044,055–39,045,485 | 176.9 kb | Distal (>10kb) Multiome | 636 | |
| chr4:39,135,136–39,135,640 | 267.7 kb | Distal (>10kb) Multiome | 399 |
Genomic view of the FAM114A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.