The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for FAIM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAIM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAIM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,329,184–138,330,233 | 279.2 kb | Distal (>10kb) Multiome | 580 | |
| chr3:138,347,955–138,349,547 | 260.6 kb | Distal (>10kb) Multiome | 615 | |
| chr3:138,417,585–138,418,044 | 191.3 kb | Distal (>10kb) Multiome | 243 | |
| chr3:138,434,084–138,435,298 | 174.5 kb | Distal (>10kb) Multiome | 811 | |
| chr3:138,608,484–138,609,385 | 79 bp | At TSS Multiome | 803 | |
| chr3:138,834,175–138,835,445 | 225.8 kb | Distal (>10kb) Multiome | 868 | |
| chr3:138,861,682–138,863,746 | 253.7 kb | Distal (>10kb) Multiome | 879 | |
| chr3:138,879,509–138,880,571 | 270.9 kb | Distal (>10kb) Multiome | 216 | |
| chr3:138,914,877–138,916,650 | 306.8 kb | Distal (>10kb) Multiome HiCAR | 922 | |
| chr3:138,935,795–138,937,399 | 327.2 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr3:138,937,821–138,938,914 | 329.3 kb | Distal (>10kb) Multiome HiCAR | 119 | |
| chr3:138,944,879–138,947,892 | 338.2 kb | Distal (>10kb) Multiome HiCAR | 500 | |
| chr3:138,949,729–138,950,605 | 341.2 kb | Distal (>10kb) Multiome HiCAR | 149 |
Genomic view of the FAIM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.