FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FAAP24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAAP24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAAP24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:32,674,338–32,676,683 | 297.0 kb | Distal (>10kb) Multiome | 792 | |
| chr19:32,691,659–32,692,482 | 280.3 kb | Distal (>10kb) Multiome | 839 | |
| chr19:32,701,845–32,702,627 | 270.0 kb | Distal (>10kb) Multiome | 257 | |
| chr19:32,706,824–32,707,422 | 265.2 kb | Distal (>10kb) Multiome | 106 | |
| chr19:32,971,721–32,972,560 | 144 bp | At TSS Multiome | 796 | |
| chr19:32,976,358–32,976,726 | 4.1 kb | Proximal (<10kb) | 189 | |
| chr19:33,022,514–33,023,071 | 50.5 kb | Distal (>10kb) Multiome | 102 | |
| chr19:33,032,077–33,032,955 | 60.2 kb | Distal (>10kb) Multiome | 217 | |
| chr19:33,064,252–33,065,504 | 92.6 kb | Distal (>10kb) Multiome | 603 | |
| chr19:33,080,776–33,081,465 | 108.8 kb | Distal (>10kb) Multiome | 838 | |
| chr19:33,124,582–33,125,060 | 152.6 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr19:33,176,278–33,177,966 | 204.9 kb | Distal (>10kb) Multiome HiCAR | 1077 | |
| chr19:33,193,912–33,194,503 | 222.0 kb | Distal (>10kb) Multiome | 256 | |
| chr19:33,225,334–33,226,211 | 253.4 kb | Distal (>10kb) Multiome | 146 | |
| chr19:33,226,520–33,227,396 | 254.8 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the FAAP24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.