FAAH
fatty acid amide hydrolase | FAAH-1, FAAH1

This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

Biological processes 32 terms
amidase activity (GO:0004040)amidase activity (GO:0004040)arachidonate metabolic process (GO:0019369)cytoskeleton (GO:0005856)endomembrane system (GO:0012505)endoplasmic reticulum membrane (GO:0005789)fatty acid amide hydrolase activity (GO:0017064)fatty acid amide hydrolase activity (GO:0017064)fatty acid amide hydrolase activity (GO:0017064)fatty acid amide hydrolase activity (GO:0017064)fatty acid amide hydrolase activity (GO:0017064)fatty acid catabolic process (GO:0009062)fatty acid catabolic process (GO:0009062)fatty acid catabolic process (GO:0009062)fatty acid metabolic process (GO:0006631)glutamatergic synapse (GO:0098978)hydrolase activity, acting on ester bonds (GO:0016788)identical protein binding (GO:0042802)lipid binding (GO:0008289)monoacylglycerol catabolic process (GO:0052651)monoacylglycerol catabolic process (GO:0052651)monoacylglycerol lipase activity (GO:0047372)monoacylglycerol lipase activity (GO:0047372)organelle membrane (GO:0031090)phospholipid binding (GO:0005543)positive regulation of vasoconstriction (GO:0045907)postsynapse (GO:0098794)presynapse (GO:0098793)protein binding (GO:0005515)regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (GO:0150036)response to ethanol (GO:0045471)response to immobilization stress (GO:0035902)
Expression (TPM)
FAAH — as a Regulated Gene

TFs regulating FAAH 0 TFs

Transcription factors with Perturb-seq knockdown data for FAAH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAAH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FAAH

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAAH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:46,131,887–46,133,691 261.3 kb Distal (>10kb) Multiome 1126
chr1:46,198,117–46,198,832 195.9 kb Distal (>10kb) Multiome 646
chr1:46,203,021–46,203,710 191.0 kb Distal (>10kb) Multiome 394
chr1:46,246,904–46,248,623 146.8 kb Distal (>10kb) Multiome 923
chr1:46,301,645–46,303,965 92.3 kb Distal (>10kb) Multiome 1035
chr1:46,340,061–46,341,413 53.6 kb Distal (>10kb) Multiome 967
chr1:46,394,021–46,394,849 102 bp At TSS Multiome 795
chr1:46,401,942–46,402,392 7.9 kb Proximal (<10kb) Multiome 511
chr1:46,406,082–46,407,120 12.2 kb Distal (>10kb) Multiome 299
chr1:46,442,171–46,443,351 48.4 kb Distal (>10kb) Multiome 649
chr1:46,448,113–46,448,679 54.2 kb Distal (>10kb) Multiome 143
chr1:46,466,221–46,467,348 72.4 kb Distal (>10kb) Multiome 398
chr1:46,489,045–46,490,312 95.4 kb Distal (>10kb) Multiome 381
chr1:46,516,974–46,517,563 122.9 kb Distal (>10kb) Multiome 328
chr1:46,526,636–46,527,311 132.7 kb Distal (>10kb) Multiome 225
chr1:46,532,918–46,533,689 138.9 kb Distal (>10kb) Multiome 254
chr1:46,603,644–46,604,906 210.0 kb Distal (>10kb) Multiome 784
chr1:46,616,228–46,617,226 222.3 kb Distal (>10kb) Multiome 517
chr1:46,667,821–46,668,764 274.1 kb Distal (>10kb) Multiome 668

Genome Browser

Genomic view of the FAAH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:46,121,887 – 46,678,764
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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