The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for EYS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EYS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EYS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:63,571,631–63,574,599 | 233.9 kb | Distal (>10kb) Multiome | 1258 | |
| chr6:63,598,023–63,599,017 | 207.6 kb | Distal (>10kb) Multiome HiCAR | 665 | |
| chr6:63,634,548–63,637,008 | 171.5 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:63,788,163–63,789,367 | 17.4 kb | Distal (>10kb) Multiome | 152 | |
| chr6:63,805,507–63,806,337 | at TSS | At TSS | 259 |
Genomic view of the EYS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.