Enables 3'-5'-RNA exonuclease activity and telomerase RNA binding activity. Involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of telomerase RNA localization to Cajal body. Located in cytosol; euchromatin; and nuclear lumen. Part of nuclear exosome (RNase complex) and small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EXOSC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:10,835,650–10,836,437 | 263.8 kb | Distal (>10kb) Multiome | 422 | |
| chr1:10,866,886–10,867,599 | 232.6 kb | Distal (>10kb) Multiome | 364 | |
| chr1:11,011,823–11,013,364 | 87.4 kb | Distal (>10kb) Multiome | 974 | |
| chr1:11,052,805–11,053,698 | 46.6 kb | Distal (>10kb) Multiome | 314 | |
| chr1:11,059,469–11,060,508 | 39.7 kb | Distal (>10kb) Multiome | 659 | |
| chr1:11,099,300–11,100,191 | 96 bp | At TSS Multiome | 798 | |
| chr1:11,262,158–11,262,957 | 162.8 kb | Distal (>10kb) Multiome | 805 | |
| chr1:11,272,615–11,274,143 | 173.3 kb | Distal (>10kb) Multiome | 912 | |
| chr1:11,311,832–11,312,672 | 212.4 kb | Distal (>10kb) Multiome | 49 |
Genomic view of the EXOSC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.