This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for EXOC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:231,039,156–231,041,267 | 297.6 kb | Distal (>10kb) Multiome | 661 | |
| chr1:231,161,989–231,163,833 | 175.4 kb | Distal (>10kb) Multiome | 768 | |
| chr1:231,211,148–231,211,998 | 126.3 kb | Distal (>10kb) Multiome | 631 | |
| chr1:231,240,746–231,241,633 | 96.6 kb | Distal (>10kb) Multiome | 834 | |
| chr1:231,337,024–231,338,750 | 151 bp | At TSS Multiome | 881 | |
| chr1:231,420,882–231,422,905 | 84.5 kb | Distal (>10kb) Multiome | 956 | |
| chr1:231,528,042–231,528,983 | 190.7 kb | Distal (>10kb) Multiome | 873 | |
| chr1:231,626,385–231,627,805 | 289.6 kb | Distal (>10kb) Multiome | 776 |
Genomic view of the EXOC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.