The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for EXOC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,827,420–75,828,293 | 275.9 kb | Distal (>10kb) Multiome | 404 | |
| chr17:75,830,158–75,830,695 | 273.3 kb | Distal (>10kb) Multiome | 190 | |
| chr17:75,832,912–75,833,396 | 270.6 kb | Distal (>10kb) Multiome | 104 | |
| chr17:75,845,103–75,845,662 | 258.4 kb | Distal (>10kb) Multiome | 703 | |
| chr17:75,854,955–75,856,363 | 248.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:75,877,486–75,878,900 | 225.7 kb | Distal (>10kb) Multiome | 884 | |
| chr17:75,896,392–75,897,754 | 206.8 kb | Distal (>10kb) Multiome | 831 | |
| chr17:75,904,371–75,905,532 | 198.7 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:75,940,734–75,941,471 | 162.6 kb | Distal (>10kb) Multiome | 982 | |
| chr17:75,978,646–75,980,102 | 124.4 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 119.9 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 89.3 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 74.1 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,072,173–76,072,853 | 31.2 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 29.1 kb | Distal (>10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 46 bp | At TSS Multiome | 798 | |
| chr17:76,106,042–76,106,355 | 2.3 kb | Proximal (<10kb) | 324 | |
| chr17:76,121,142–76,122,265 | 17.8 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 29.0 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 31.5 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 37.7 kb | Distal (>10kb) Multiome | 616 | |
| chr17:76,240,278–76,241,169 | 136.9 kb | Distal (>10kb) Multiome | 560 | |
| chr17:76,264,834–76,266,286 | 161.4 kb | Distal (>10kb) Multiome HiCAR | 868 | |
| chr17:76,353,245–76,354,535 | 250.3 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 280.8 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 282.3 kb | Distal (>10kb) Multiome | 935 |
Genomic view of the EXOC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.