Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization; exocytosis; and peptide hormone secretion. Predicted to be located in secretory granule. Predicted to be part of exocyst. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EXOC3L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOC3L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOC3L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,183,333–67,184,856 | 5.3 kb | Proximal (<10kb) | 886 | |
| chr16:67,185,256–67,185,693 | 4.4 kb | Proximal (<10kb) | 740 | |
| chr16:67,191,949–67,192,449 | 1.8 kb | Proximal (<10kb) | 781 | |
| chr16:67,198,366–67,198,758 | 8.2 kb | Proximal (<10kb) | 193 | |
| chr16:67,198,940–67,200,211 | 8.8 kb | Proximal (<10kb) | 325 |
Genomic view of the EXOC3L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.