Enables GTPase activator activity and small GTPase binding activity. Involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EVI5L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EVI5L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EVI5L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,533,976–7,536,472 | 294.6 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 278.9 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 274.9 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 234.4 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 200.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 193.1 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 149.4 kb | Distal (>10kb) Multiome | 679 | |
| chr19:7,829,238–7,830,666 | 353 bp | At TSS Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 23.2 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 32.5 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 38.7 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 41.9 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 44.4 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 58.3 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 73.5 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 87.7 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 90.4 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 96.1 kb | Distal (>10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 113.6 kb | Distal (>10kb) Multiome | 974 | |
| chr19:8,001,954–8,002,874 | 172.3 kb | Distal (>10kb) Multiome | 475 | |
| chr19:8,005,202–8,006,197 | 175.5 kb | Distal (>10kb) Multiome | 729 | |
| chr19:8,050,174–8,051,154 | 220.5 kb | Distal (>10kb) Multiome | 467 |
Genomic view of the EVI5L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.