Transcription factors with Perturb-seq knockdown data for EVA1CP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EVA1CP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EVA1CP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,757,971–67,758,804 | 1.0 kb | Proximal (<10kb) | 61 | |
| chr11:67,759,685–67,760,168 | 2.7 kb | Proximal (<10kb) | 9 | |
| chr11:67,761,288–67,761,538 | 4.3 kb | Proximal (<10kb) | 8 | |
| chr11:67,764,985–67,765,441 | 8.0 kb | Proximal (<10kb) | 6 |
Genomic view of the EVA1CP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.