Enables heparin binding activity. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EVA1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EVA1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EVA1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:32,278,475–32,279,634 | 133.7 kb | Distal (>10kb) Multiome | 828 | |
| chr21:32,305,933–32,306,620 | 106.5 kb | Distal (>10kb) Multiome | 126 | |
| chr21:32,392,560–32,393,703 | 19.7 kb | Distal (>10kb) Multiome | 812 | |
| chr21:32,403,238–32,403,414 | 9.3 kb | Proximal (<10kb) | 201 | |
| chr21:32,412,001–32,413,390 | 128 bp | At TSS Multiome | 469 | |
| chr21:32,569,288–32,570,076 | 157.0 kb | Distal (>10kb) Multiome HiCAR | 731 | |
| chr21:32,612,057–32,613,158 | 199.9 kb | Distal (>10kb) Multiome | 971 |
Genomic view of the EVA1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.