Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Located in cytoplasmic side of plasma membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ESYT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESYT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESYT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,174,233–138,175,030 | 259.8 kb | Distal (>10kb) Multiome | 817 | |
| chr3:138,186,777–138,188,242 | 247.2 kb | Distal (>10kb) Multiome | 867 | |
| chr3:138,329,184–138,330,233 | 104.7 kb | Distal (>10kb) Multiome | 580 | |
| chr3:138,347,955–138,349,547 | 86.1 kb | Distal (>10kb) Multiome | 615 | |
| chr3:138,417,585–138,418,044 | 16.8 kb | Distal (>10kb) Multiome | 243 | |
| chr3:138,434,084–138,435,298 | 4 bp | At TSS Multiome | 811 | |
| chr3:138,435,422–138,435,757 | 837 bp | At TSS | 62 | |
| chr3:138,608,484–138,609,385 | 174.4 kb | Distal (>10kb) Multiome | 803 | |
| chr3:138,914,877–138,916,650 | 481.3 kb | Distal (>10kb) Multiome HiCAR | 922 | |
| chr3:138,935,795–138,937,399 | 501.7 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr3:138,944,879–138,947,892 | 512.6 kb | Distal (>10kb) Multiome HiCAR | 500 | |
| chr3:138,949,729–138,950,605 | 515.7 kb | Distal (>10kb) Multiome HiCAR | 149 |
Genomic view of the ESYT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.