Enables identical protein binding activity. Predicted to be involved in sterol biosynthetic process. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ERG28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERG28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERG28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:75,419,070–75,419,695 | 241.4 kb | Distal (>10kb) Multiome | 358 | |
| chr14:75,427,222–75,428,490 | 232.9 kb | Distal (>10kb) Multiome | 640 | |
| chr14:75,452,945–75,453,577 | 207.6 kb | Distal (>10kb) Multiome | 408 | |
| chr14:75,577,727–75,579,221 | 82.3 kb | Distal (>10kb) Multiome | 646 | |
| chr14:75,604,930–75,606,141 | 55.4 kb | Distal (>10kb) Multiome | 195 | |
| chr14:75,646,886–75,647,914 | 13.4 kb | Distal (>10kb) Multiome | 156 | |
| chr14:75,654,222–75,654,432 | 6.4 kb | Proximal (<10kb) | 253 | |
| chr14:75,660,453–75,661,746 | 240 bp | At TSS Multiome | 786 | |
| chr14:75,711,559–75,712,330 | 51.2 kb | Distal (>10kb) Multiome | 434 | |
| chr14:75,972,579–75,973,063 | 311.9 kb | Distal (>10kb) Multiome HiCAR | 56 | |
| chr14:75,982,219–75,983,158 | 321.7 kb | Distal (>10kb) Multiome HiCAR | 459 | |
| chr14:75,985,670–75,986,242 | 325.0 kb | Distal (>10kb) Multiome HiCAR | 373 |
Genomic view of the ERG28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.