This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EPS8L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPS8L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPS8L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:55,069,129–55,069,807 | 6.1 kb | Proximal (<10kb) | 288 | |
| chr19:55,075,680–55,075,968 | at TSS | At TSS | 143 | |
| chr19:55,080,038–55,082,744 | 4.2 kb | Proximal (<10kb) | 639 | |
| chr19:55,083,444–55,083,832 | 7.6 kb | Proximal (<10kb) | 58 | |
| chr19:55,086,246–55,087,525 | 5.9 kb | Proximal (<10kb) | 258 | |
| chr19:55,088,649–55,088,888 | 8.3 kb | Proximal (<10kb) | 130 |
Genomic view of the EPS8L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.