The protein encoded by this gene belongs to the plakin family of proteins, which play a role in the organization of cytoskeletal architecture. This family member is composed of several highly homologous plakin repeats. It may function to maintain the integrity of keratin intermediate filament networks in epithelial cells. Studies of the orthologous mouse protein suggest that it accelerates keratinocyte migration during wound healing. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for EPPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,577,641–143,578,799 | 300.1 kb | Distal (>10kb) Multiome | 470 | |
| chr8:143,596,744–143,599,643 | 280.9 kb | Distal (>10kb) Multiome | 973 | |
| chr8:143,608,979–143,610,357 | 268.7 kb | Distal (>10kb) Multiome | 735 | |
| chr8:143,617,068–143,618,380 | 260.8 kb | Distal (>10kb) Multiome | 823 | |
| chr8:143,635,715–143,636,601 | 242.5 kb | Distal (>10kb) Multiome | 786 | |
| chr8:143,684,308–143,684,747 | 194.0 kb | Distal (>10kb) Multiome | 686 | |
| chr8:143,716,075–143,716,913 | 162.2 kb | Distal (>10kb) Multiome | 311 | |
| chr8:143,733,345–143,734,440 | 144.6 kb | Distal (>10kb) Multiome | 663 | |
| chr8:143,740,039–143,740,754 | 138.0 kb | Distal (>10kb) Multiome | 308 | |
| chr8:143,771,202–143,772,221 | 106.7 kb | Distal (>10kb) Multiome | 405 | |
| chr8:143,814,945–143,816,493 | 62.7 kb | Distal (>10kb) Multiome | 893 | |
| chr8:143,828,724–143,829,946 | 49.1 kb | Distal (>10kb) Multiome | 933 | |
| chr8:143,840,284–143,841,979 | 37.3 kb | Distal (>10kb) Multiome HiCAR | 551 | |
| chr8:143,877,814–143,879,346 | 94 bp | At TSS Multiome | 444 | |
| chr8:143,941,814–143,942,929 | 63.8 kb | Distal (>10kb) Multiome | 630 | |
| chr8:143,943,562–143,944,432 | 65.6 kb | Distal (>10kb) Multiome | 587 | |
| chr8:143,951,583–143,954,394 | 75.4 kb | Distal (>10kb) Multiome | 943 | |
| chr8:143,972,817–143,973,908 | 95.1 kb | Distal (>10kb) Multiome | 436 | |
| chr8:143,976,288–143,977,568 | 98.6 kb | Distal (>10kb) Multiome | 738 | |
| chr8:143,989,521–143,991,038 | 111.6 kb | Distal (>10kb) Multiome | 596 | |
| chr8:144,049,063–144,051,761 | 172.2 kb | Distal (>10kb) Multiome | 342 | |
| chr8:144,060,259–144,061,087 | 182.3 kb | Distal (>10kb) Multiome | 727 | |
| chr8:144,078,142–144,079,235 | 200.2 kb | Distal (>10kb) Multiome | 912 | |
| chr8:144,082,187–144,083,105 | 204.1 kb | Distal (>10kb) Multiome | 763 | |
| chr8:144,094,454–144,095,491 | 216.5 kb | Distal (>10kb) Multiome | 798 | |
| chr8:144,103,485–144,105,242 | 225.9 kb | Distal (>10kb) Multiome | 1033 | |
| chr8:144,108,038–144,108,663 | 229.9 kb | Distal (>10kb) Multiome | 137 | |
| chr8:144,137,565–144,138,500 | 259.3 kb | Distal (>10kb) Multiome | 817 | |
| chr8:144,146,820–144,149,073 | 269.5 kb | Distal (>10kb) Multiome | 790 |
Genomic view of the EPPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.