Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Located in several cellular components, including clathrin-coated vesicle; cytoplasmic side of plasma membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EPN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,532,601–50,532,976 | at TSS | At TSS | 308 | |
| chr17:50,534,324–50,534,541 | 1.6 kb | Proximal (<10kb) | 268 | |
| chr17:50,541,672–50,542,697 | 8.9 kb | Proximal (<10kb) | 772 |
Genomic view of the EPN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.