This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for EPHX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPHX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPHX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:27,274,263–27,275,075 | 216.6 kb | Distal (>10kb) Multiome | 573 | |
| chr8:27,310,458–27,311,925 | 179.8 kb | Distal (>10kb) Multiome | 871 | |
| chr8:27,490,586–27,491,648 | 74 bp | At TSS Multiome | 837 | |
| chr8:27,592,228–27,592,758 | 101.3 kb | Distal (>10kb) Multiome | 524 | |
| chr8:27,608,493–27,608,956 | 117.6 kb | Distal (>10kb) Multiome | 168 | |
| chr8:27,614,194–27,615,207 | 123.6 kb | Distal (>10kb) Multiome | 844 | |
| chr8:27,633,626–27,634,225 | 142.7 kb | Distal (>10kb) Multiome | 300 | |
| chr8:27,729,944–27,730,631 | 239.1 kb | Distal (>10kb) Multiome | 159 | |
| chr8:27,772,146–27,773,026 | 281.4 kb | Distal (>10kb) Multiome | 823 | |
| chr8:27,774,174–27,774,993 | 283.3 kb | Distal (>10kb) Multiome | 712 |
Genomic view of the EPHX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.