Predicted to enable PH domain binding activity; cytoskeletal protein binding activity; and structural molecule activity. Involved in positive regulation of protein localization to cell cortex. Located in several cellular components, including cell cortex; cell junction; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EPB41L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPB41L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPB41L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:130,993,909–130,995,471 | 68.3 kb | Distal (>10kb) Multiome | 186 | |
| chr6:131,061,192–131,061,673 | 1.6 kb | Proximal (<10kb) | 170 | |
| chr6:131,061,961–131,064,084 | 89 bp | At TSS Multiome | 841 | |
| chr6:131,135,132–131,136,378 | 72.4 kb | Distal (>10kb) Multiome | 830 | |
| chr6:131,294,899–131,295,742 | 232.1 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the EPB41L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.