Transcription factors with Perturb-seq knockdown data for ENSG00000291208. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291208 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291208, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:45,573,677–45,575,925 | 194.5 kb | Distal (>10kb) Multiome | 366 | |
| chr7:45,641,919–45,642,829 | 126.8 kb | Distal (>10kb) Multiome | 162 | |
| chr7:45,768,480–45,769,428 | 34 bp | At TSS Multiome | 528 | |
| chr7:45,920,336–45,922,109 | 152.0 kb | Distal (>10kb) Multiome | 377 | |
| chr7:46,015,214–46,016,175 | 246.5 kb | Distal (>10kb) Multiome | 250 | |
| chr7:47,190,020–47,191,241 | 1421.5 kb | Distal (>10kb) Multiome HiCAR | 182 |
Genomic view of the ENSG00000291208 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.